Large macromolecular assemblies play an important role in biology. The study of their structure, stability and dynamic behavior remains very challenging and although biophysical techniques play a major role in investigating their properties they are insufficient to provide a complete understanding.

On the other hand simulations offer a convenient and useful approach for obtaining structural and dynamic properties of large macromolecules at an atomic level, but need to be conducted in close relationship with experiments because of the inherent uncertainties in this field.